SERVICES

HOW CAN WE HELP?
We are putting our technology and knowledge at the service of society. Our technological platforms and infrastructures are prepared to provide high-value services to the private sector
and undertake custom, market-driven R&D projects.
TECHNOLOGICAL PLATFORMS
We are putting our technology and know-how at your disposal to facilitate the development of real-world healthcare solutions. Our newest advances and technologies are translated straight from the laboratory into high-quality services for the private industrial sector.
We have grown our highly valued service to 5 platforms that cover most fields in Healthcare Biotechnology, from in silico capabilities to industrial biotechnological developments. New infrastructures, equipment, and know-how will be incorporated into our range of services to meet the increasing demands of the market.

SKIN RESEARCH PLATFORM (SRP)
Cosmetic principles, dermatology

MOLECULAR MODELLING PLATFORM (MiMIc)
Virtual screening of structural databases for rational molecular design.

TRANSLATIONAL NANOTECHNOLOGY PLATFORM (PATeNT)
R&D capabilities, services
SKIN RESEARCH PLATFORM (SRP)
The SRP is at the service of cosmetic companies with a need for cosmeticeutical principles,
design and development with a solid scientific foundation.
This platform is a blend of our expertise in molecular cosmetics and the development of natural extracts with dermatological applications. Its mission is to become a place where the excellence of our academic research meets the clinical
The SRP is currently used by companies interested in characterizing their products both at the analytical and functional level.
We offer a complete in vitro portfolio of activities, including:
Custom R&D projects for the design and development of dermatological products.
Technological assistance in the development of dermatological products.
Analytical characterization of products, ingredients, additives and/or allergens with chromatographic techniques.
Determination of particle size of cosmetic products and ingredients using DLS technology.
Analysis of biological activity on in vitro assays, including
in vitro enzymatic tests for cosmetic activities (e.g. antiaging and solar protection) and a complete collection of cellular models covering all the skin layers (melanocytes, keratinocytes, fibroblast
A direct interaction with IDiBE Molecular Modelling Platform which covers all the in silico screening of new active molecules on molecular targets of cosmetic interest.
Development of transdermal patches based on electrospun nanofibers with encapsulating properties and controlled release.
Development of transdermal patches based on electrospun nanofibers with encapsulating properties and controlled release.
The SRP is a joint initiative between IDiBE, the technological institutes AITEX, INESCOP and AIJU, the private companies BIOARRAY and LIPOTEC and the Center of Dermatology and Aesthetics of Alicante. As a public-private enterprise, the aim of the platform is to establish strong connections with our stakeholders to facilitate the development of marketable products and services.
MOLECULAR MODELLING PLATFORM (MiMIc)
MiMic integrates our capabilities in bioinformatics with the virtual screening of biomolecular structure databases aimed at the design of macromolecular structures.
Rational protein modification:
protein engineering.
Determination of protein interaction maps, including protein-protein and protein-lipid interactions.
Identification of novel active compounds through molecular docking and virtual screening from chemical libraries or natural extracts.
Molecular dynamics simulation has been incorporated to recreate the macromolecule dynamics in a native environment, including proteins, lipids, water
TRANSLATIONAL NANOTECHNOLOGY PLATFORM (PATeNT)
Designed to exploit our competitive, translational know-how and equipment in the field of nanotechnology applications.
The mission of PATeNT is to provide R&D capabilities, services, and assistance in the design and development of nanostructures, nanoparticles
Our nanotechnology know-how
Design and development of nanostructures for biotechnology and biomedicine applications.
Design and development of nanocarriers as vehicles of biologically active compounds.
Design and development of biosensors.
The PATeNT platform has acquired new equipment thanks to an intervention co-funded by the European Union through the Programa Operativo del Fondo Europeo de Desarrollo Regional (FEDER) from the Comunitat Valenciana 2014-2020 (PROJECT: IDIFEDER2018/020).
- Nano scanning differential calorimeter (DSC) from TA Instruments specially designed for the study of conformational transitions of dissolving biomolecules (proteins, nucleic acids, etc.) induced by temperature increase.
- Particle analyzer using dynamic light scattering (DLS) with non-invasive backscatter optics (NIBS) and flow cell for coupling to chromatography systems.
- Ultra High Pressure Liquid Chromatography System (uHPLC) Shimadzu, from the NEXERA series, coupled to a triple quadrupole mass spectrometry detector model LCMS-8050 for tandem masses (QqQ-MS / MS).
- Schottky hot cathode field emission (FESEM) model SIGMA 300 VP scanning electron microscope has been installed. It can work with voltages between 0.02 and 30 kV and has a resolution of 1.0 nm at 15 kV and 1.6 nm at 1 kV.

ION CHANNEL HIGH THROUGHPUT SCREENING PLATFORM (PuCCiNI)
Design, identification, and validation of ion channel modulatory molecules.

PILOT EXTRACTION PLANT FOR BIOTECH PROCESS OPTIMIZATION PLATFORM (PERfOrM)
Industrial R&D projects for pharmacology, cosmetics, nutraceuticals, functional foods
ION CHANNEL HIGH THROUGHPUT SCREENING PLATFORM (PuCCiNI )
Design, identification, and validation of modulatory molecules of this family of proteins
Ion channels are very attractive drug targets, as they are involved in several diseases, from cancer to inflammation and neurodegeneration. Thus, there is an increased interest from pharmaceutical companies in the development of pharmaceutically active molecules that target these proteins. Furthermore, they are involved in skin physiology and nutrition, which expands their interest to cosmetic and nutraceutical companies.
IDiBE, in collaboration with SICI and RECI, has established
Assay development and validation.
Library screening.
Hit identification and lead validation for development (clinical, cosmetic, nutraceutical).
PuCCiNI has already attracted the interest of drug discovery platforms such as the
Our equipment includes manual and automated patch clamp setups, multiarray electrophysiology, automated liquid dispensers, fluorescence and luminescence plate readers, high content microscopy, microfluidic technology, neuronal primary cultures, and confocal microscopy.
PILOT EXTRACTION PLANT FOR BIOTECH PROCESS OPTIMIZATION PLATFORM (PERfOrM)
Industrial R&D projects and technology development for companies in the fields of pharmacology, cosmetics, nutraceuticals, functional foods and agronomy.
PERfOrM readily applies our know-how to the transformation and/or optimization of industrial processes into market-ready products, processes, and services. Our mission is to generate
Quality control or development of new biotechnological products and processes.
Design, optimization and industrial scaling of biotechnological processes.
Extraction, purification
INFRASTRUCTURES AND EQUIPMENT
IDiBE is well equipped with the necessary infrastructures and equipment to cover all

CELL CULTURE UNIT
Fully equipped for primary cultures, cell lines, media preparation, cell manipulation

BIOSAFETY LEVEL 2 LABORATORY
A safe environment for the culture of pathogenic bacteria and viruses.

IMAGING ACQUISITION AND ANALYSIS
Facilities for cell population analysis, high content microscopy
CELL CULTURE UNIT
This unit is equipped with 8 laminar flow cabinets (one with high biological safety) 8 CO2 incubators for eukaryotes with an automatic central CO2 distribution. It is also equipped with an electroporator for eukaryotes and accessory equipment for the preparation of culture media (thermostated baths with
This unit is divided
This unit has five -80°C ultra-freezers each with 500 liters capacity, (two of which have a safety system and are connected to CO2 bullets), two –30°C freezers, two lyophilizers and several liquid nitrogen containers of liquid nitrogen various dimensions (from 140 to 25 liters capacity) for sample storage.
BIOSAFETY LEVEL 2 LABORATORY
A BL-2 laboratory will be incorporated for culturing pathogenic bacteria and viruses safely. Pathogens intended to be used are agents of
IMAGING ACQUISITION AND ANALYSIS
Equipped with two Coulter Epics XL flow cytometers for cell population analysis, two Nikon and Leica inverted fluorescence microscopes with Vis/UV lenses and image processing equipment, two Zeiss SLM5 Pascal confocal microscopes, equipped with Argon and Helium-Neon lasers, as well as small accessory equipment, a FESEM microscope, and In-cell analyzer for high content microscopy.

ANALYTICAL FACILITIES

ELECTROPHYSIOLOGY FACILITIES
Comprehensive equipment for a full range of electrophysiological measurements.

PROTEIN PRODUCTION, STRUCTURE AND THERMODYNAMICS
Designed to effectively produce, measure and analyze proteins and protein samples.
ANALYTICAL FACILITIES
A. Analysis and chromatographic fractionation unit:
Merck Hitachi high performance liquid chromatography system (HPLC), with an automatic sampler, photodiode detector, luminous evaporative dispersion detector and fluorescence detector; a semi-preparative Merck-Knauer HPLC system with dual pumps for gradient separation and a Vis/UV detector; Agilent-Hewlett Packard Series 1100 HPLC equipment with automatic sampler and photodiode
detector; mass spectrometry with electrospray ionization (ESI) and ion trap detector in MS/MS mode (Bruker Esquire 3000 Plus).
B. Nucleic acid processing unit: Gene Amp PCR System 2700 thermal cycler (Applied Biosystems) with a temperature control system for conventional PCR; two real time quantitative PCR devices from Applied Biosystems;
ELECTROPHYSIOLOGY FACILITIES
Equipped with an automatic
PROTEIN PRODUCTION, STRUCTURE AND THERMODYNAMICS
A. Protein production and purification unit. Three incubators for bacteria growth, along with a hot room kept a 37ºC, and a fermenter (New Brunswick,
B. Microcalorimetric analysis unit: This unit has a high sensitivity VP-DSC calorimeter and a high sensitivity VP-ITC isothermal titration. It also has a differential scanning MC-2 microcalorimeter and an isothermal titration Omega calorimeter which are somewhat older and less sensitive. All of this equipment is from Microcal, Inc. Apart from this equipment, the unit also has a differential Perkin Elmer DSC-6 calorimeter, which is highly useful for measuring lipids and accessory equipment for sample preparation.
C. Molecular spectroscopy unit: Two Jasco spectropolarimeters mod. 715 and 815 for circular dichroism measurements; a SLM spectrofluorometer with accessories for fluorescence polarization measurements, spectra recordings, double wavelength excitation and rapid kinetics; a steady state PTI fluorometer for excitation-emission polarization spectra with software which permits temperature scanning and working with solid samples. It also has a rapid kinetic “stopped-flow” Applied photophysics apparatus with three channels (absorbance, fluorescence and circular dichroism). In addition, it has a Thermo scientific “Nanodrop 1000” 39 Spectrophotometer, which can obtain an emission spectrum between 220 y 750 nm, from just a 1-2 μl sample. It has several programmed application modules for nucleic acids, cell cultures and protein quantification, etc.
D. Structure unit:
a) NMR AVANCE 500, spectrometer with shielded magnet and TOPSPIN 2.0. software. Three channels for biomolecular studies, with triple resonance and BVT temperature unit. Gradient unit, one TXI probe
b) TBI Inverse probe for triple resonance with Deuterium lock for 1H/13C/BB broadband. Full HR-MAS accessory with

ANIMAL FACILITIES
Fully equipped and accessible to researchers with an approved protocol.

INDUSTRIAL PILOT PLANT FACILITY
Semi-industrial manufacturing of biotechnological products and extraction of bioactive compounds.
ANIMAL FACILITIES
An animal facility is located in the University campus to host rodents, amphibians, and fish. These facilities are well equipped, including isolation rooms for
INDUSTRIAL PILOT PLANT FACILITY
Apart from a complete set of pilot machinery for semi-industrial production of juices, beverages (alcoholic and non- alcoholic), fermented products and extraction of bioactive compounds from vegetable, herbs
- Extraction Equipment
- Separation Equipment; Filters, Centrifuges, Finishers & Others
- F&D, Dryers, Evaporator and Steam Distillation equipment
- Pasteurization & Sterilization Equipment
- Filling & Packing Equipment
- Fermenters and Bioreactors
- Auxiliary and Other Equipment