RESEARCH

WHAT ARE WE WORKING ON?

Our multidisciplinary research program combines scientific excellence with a unique market-oriented vision to develop innovative products and technologies for the healthcare industry. 

Frontiers in Endocrinology

Tuduri, E., et al., (2018)

Timing of Exposure and Bisphenol-A: Implications for Diabetes Development

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Marine Drugs

Ruiz-Torres, V., et al. (2018)

New Mammalian Target of Rapamycin (mTOR) Modulators Derived from Natural Product Databases and Marine Extracts by Using Molecular Docking Techniques

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Current Medicinal Chemistry

Alvarez-Martinez, F.J., et al. (2018)

Antimicrobial Capacity of Plant Polyphenols against Gram-positive Bacteria: A Comprehensive Review

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Frontiers in Molecular Bioscience

Artero-Morales, M., et al. (2018)

TRP Channels as Potential Targets for Sex-Related Differences in Migraine Pain

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European Journal of Medicinal Chemistry

Balsera, B., et al. (2018)

Amino acid and peptide prodrugs of diphenylpropanones positive allosteric modulators of α7 nicotinic receptors with analgesic activity

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Applied and Environmental Microbiology

Bello-Gil, D., et al. (2018)

Poly-3-Hydroxybutyrate Functionalization with BioF-Tagged Recombinant Proteins

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Microbial Biotechnology

Bello-Gil, D., et al. (2018)

An enzymatic system for decolorization of wastewater dyes using immobilized CueO laccase‐like multicopper oxidase on poly‐3‐hydroxybutyrate

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Journal of Medicinal Chemistry

Bertamino, A., et al. (2018)

Identification of a Potent Tryptophan-Based TRPM8 Antagonist With in Vivo Analgesic Activity

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Food and Function

Boix-Castejon, M., et al. (2018)

Hibiscus and lemon verbena polyphenols modulate appetite-related biomarkers in overweight subjects: a randomized controlled trial

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Journal of Functional Foods

Cadiz-Gurrea, M. D. L. L., et al. (2018)

Bioassay-guided purification of Lippia citriodora polyphenols with AMPK modulatory activity

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International Journal of Molecular Sciences

Contreras, L. M., et al. (2018)

The Cyanobacterial Ribosomal-Associated Protein LrtA from Synechocystis sp. PCC 6803 Is an Oligomeric Protein in Solution with Chameleonic Sequence Properties

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Diabetologia

Coomans de Brachène, A., et al. (2018).

IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells

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Carcinogenesis

Corominas-Faja, B., et al. (2018)

Extra-virgin olive oil contains a metabolo-epigenetic inhibitor of cancer stem cells

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Food Research International

de la Luz Cadiz-Gurrea, M., et al. (2018)

Different behavior of polyphenols in energy metabolism of lipopolysaccharide-stimulated cells

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United European Gastroenterology Journal

de-Madaria, E., et al. (2018)

Fluid resuscitation with lactated Ringer’s solution vs normal saline in acute pancreatitis: A triple-blind, randomized, controlled trial

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Environmental Sciences Europe

Gallo, F., et al. (2018)

Marine litter plastics and microplastics and their toxic chemical components: the need for urgent preventive measures

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Liver International

Gomez-Hurtado, I., et al. (2018)

Norfloxacin is more effective than Rifaximin in avoiding bacterial translocation in an animal model of cirrhosis

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European Journal of Nutrition

Gomez-Hurtado, I., et al. (2018)

Improved hemodynamic and liver function in portal hypertensive cirrhotic rats after administration of B. pseudocatenulatum CECT 7765

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Diabetes

Juan-Mateu, J., et al. (2018)

SRp55 Regulates a Splicing Network that Controls Human Pancreatic β-Cell Function and Survival

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Fish and Shellfish Immunology

Lama, R., et al. (2018)

Turbot (Scophthalmus maximus) Nk-lysin induces protection against the pathogenic parasite Philasterides dicentrarchi via membrane disruption

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Journal of Photochemistry and Photobiology B: Biology

Lucioli, S., et al. (2018)

Anthocyanic pigments from elicited in vitro grown shoot cultures of Vaccinium corymbosum L., cv. Brigitta Blue, as photosensitizer in natural dye-sensitized solar cells (NDSSC)

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Developmental and Comparative Immunology

M. Medina-Gali, R., et al. (2018)

Beta-glucan enhances the response to SVCV infection in zebrafish

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United European Gastroenterology Journal

Mangas-Sanjuan, C., et al. (2018)

Importance of endoscopist quality metrics for findings at surveillance colonoscopy: The detection-surveillance paradox

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Frontiers in Physiology

Martinez-Pinna, J., et al. (2018)

A Calcium-Dependent Chloride Current Increases Repetitive Firing in Mouse Sympathetic Neurons

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Fish and Shellfish Immunology

Medina-Gali, R., et al. (2018)

Chromatin immunoprecipitation and high throughput sequencing of SVCV-infected zebrafish reveals novel epigenetic histone methylation patterns involved in antiviral immune response

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PLoS ONE

Murcia, O., et al. (2018)

Colorectal cancer molecular classification using BRAF, KRAS, microsatellite instability and CIMP status: Prognostic implications and response to chemotherapy

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Journal of Steroid Biochemistry and Molecular Biology

Nadal, A., et al. (2018)

Extranuclear-initiated estrogenic actions of endocrine disrupting chemicals: Is there toxicology beyond paracelsus?

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Archives of Biochemistry and Biophysics

Neira, J. L., et al. (2018)

The histidine phosphocarrier protein, HPr, binds to the highly thermostable regulator of sigma D protein, Rsd, and its isolated helical fragments

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Biochemical Journal

Neira, J. L., et al. (2018)

The chromatin nuclear protein NUPR1L is intrinsically disordered and binds to the same proteins as its paralogue

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PLoS Pathogens

Nombela, I., and Ortega-Villaizan, M. D. M. (2018)

Nucleated red blood cells: Immune cell mediators of the antiviral response

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Journal of Developmental Origins of Health and Disease

Nuñez, P., et al. (2018)

Effects of bisphenol A treatment during pregnancy on kidney development in mice: a stereological and histopathological study

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Current Drug Metabolism

Olivares-Vicente, M., et al. (2018)

Plant-Derived Polyphenols in Human Health: Biological Activity, Metabolites and Putative Molecular Targets

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F1000Research

Ortega-Villaizan, M. M., et al. (2018)

Identification of diverse defense mechanisms in rainbow trout red blood cells in response to halted replication of VHS virus

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Nutrients

Perez-Sanchez, A., et al. (2018)

Nutraceuticals for Skin Care: A Comprehensive Review of Human Clinical Studies

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Genes

Puente-Marin, S., et al. (2018)

In Silico Functional Networks Identified in Fish Nucleated Red Blood Cells by Means of Transcriptomic and Proteomic Profiling

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Arthritis Research and Therapy

Ranieri, L., et al. (2018)

Impact of diuretics on the urate lowering therapy in patients with gout: analysis of an inception cohort

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Molecular Medicine Reports

Roca, R., et al. (2018)

β2‑adrenergic receptor functionality and genotype in two different models of chronic inflammatory disease: Liver cirrhosis and osteoarthritis

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Biochimica et Biophysica Acta - General Subjects

Santofimia-Castaño, P., et al. (2018)

Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1)

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Journal of Medicinal Chemistry

Serafini, M., et al. (2018)

Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders

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Polymers

Vazquez-Guillo, R., et al. (2018)

Advantageous Microwave-Assisted Suzuki Polycondensation for the Synthesis of Aniline-Fluorene Alternate Copolymers as Molecular Model with Solvent Sensing Properties

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Polymers

Vazquez-Guillo, R., et al. (2018)

Synthesis and Characterization of a Novel Green Cationic Polyfluorene and Its Potential Use as a Fluorescent Membrane Probe

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Food and Chemical Toxicology

Verdura, S., et al. (2018)

Silibinin is a direct inhibitor of STAT3

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Diabetes

Villamayor, L., et al. (2018)

GATA6 Controls Insulin Biosynthesis and Secretion in Adult β-Cells

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Chemistry - A European Journal

Zamora-Carreras, H., et al. (2018)

Roles of Amphipathicity and Hydrophobicity in the Micelle‐Driven Structural Switch of a 14‐mer Peptide Core from a Choline‐Binding Repeat

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Revista Clinica Española

Zapater, P. (2018)

Los estudios genéticos y la enfermedad hepática alcohólica
Genetic studies and alcoholic liver disease

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PUBLICATION HIGHLIGHTS

At IDiBE we value quality over quantity. We always strive to make significant contributions to society and healthcare and share our results in internationally recognized, peer-reviewed, high impact journals.

OUR LINES OF RESEARCH

The IDiBE research program is organized into two major lines of research that cover all activities carried out by different teams. Each research line is structured in sublines with specific objectives. The aim of this configuration is to make the most of each team’s expertise while favoring the fluent communication and synergies that emerge from multidisciplinarity. We want to promote fruitful internal collaborations, sharing of infrastructures, and productive use of all resources.

1. MOLECULAR DESIGN AND CELL SIGNALING

Studying structure-function relations of molecules and the mechanisms of cell signaling.

The main focus of this line is the structure-function relations of small molecules and macromolecules. With this knowledge, we aim to transform their activity for biotechnological purposes and design better ligands that modulate their function, as well as nanotechnology-based systems that enhance their delivery to the site of action.

An additional objective is to understand the cell signaling mechanisms triggered by environmental signals such as endocrine disruptors and other pollutants that may be the underlying cause of diseases with an increase in prevalence. By identifying the molecular components of these pathways, we seek to validate targets for drug intervention.

This research line involves 8 research groups. The variety of scientific backgrounds of the researchers involved allows for a multidisciplinary approach of these societal and technological challenges.

MOLECULAR INTERACTIONS, PROTEIN BIOPHYSICS AND ENGINEERING

Understanding interactions to rationally design or modify molecules.

DESIGN AND VALIDATION OF NANOSTRUCTURES

Developing nanostructures with healthcare and biotechnological applications.

DESIGN OF ACTIVE MOLECULES

Identifying molecular components with potential applications in healthcare.

MOLECULAR INTERACTIONS, PROTEIN BIOPHYSICS AND ENGINEERING

Understanding interactions to rationally design or modify molecules with desirable activities.

Much of the biological activity of biomolecules is based on their ability to recognize one another and form reversible non-covalent complexes. Molecular interaction processes established in physiological conditions have been evolutionarily optimized in both kinetic and thermodynamic (affinity) aspects, reaching a high level of specificity which confers an exquisite regulation on the existing macromolecular interactions in the cell environment. The main objective of this research sub-line is to understand the principles underlying protein-protein, protein-lipid and protein-ligand interactions, as well as the partitioning of molecules into the cell membranes.

Knowledge about determinants that define the kinetics and energy of macromolecular complexes formation is fundamental for achieving a truly rational design of new biomolecules with the desired activities, or the rational modification biomacromolecules activity such as proteins through the selective modification of their primary sequence (so-called protein engineering). The research projects in this subline are:

Mapping the conformational states of the selectivity filter in ion channels: towards understanding permeation, selectivity and inactivation.

Profs. José M. González Ros
and José A. Poveda

Molecular mechanism of action of direct-acting antivirals against the Zika and Dengue viruses.

Prof. Ana M. Fernández Escamilla

Macromolecular interactions and druggability of intrinsically disordered proteins involved in pancreatic cancer.

Profs. José L. Neira, Javier Gómez and Rocio Esquembre

DESIGN AND VALIDATION OF NANOSTRUCTURES

Developing nanostructures with healthcare and biotechnological applications.

Nanotechnology is currently an essential field in biotechnology, particularly in the design of biosensors for point-of-care usage and the design delivery systems that increase drug targeting and decrease tissue toxicity. This sub-line aims to design nanostructures, including nanoparticles and nanofibers that have biotechnological and healthcare applications. The research projects in this subline are:

Synthesis and design of multifunctional nanostructures for biotechnology and biomedicine applications.

Profs. Ricardo Mallavia, Reyes Mateo and Mª José MartínezTomé

Biosensors based on fluorescent nanosystems for drug screening and health monitoring.

Profs. Reyes Mateo, Ricardo Mallavia and Mª José Martínez Tomé

Design of nanoparticles for drug vehiculization, delivery and controlled release.

Profs. Javier Gómez and Rocio Esquembre

DESIGN OF ACTIVE MOLECULES

Identifying molecular components with potential applications in healthcare.

The identification and design of bioactive molecules for different applications is first based on a computational strategy using molecular modeling, docking and dynamics. In addition, in silico screening is also applied to virtual libraries composed of thousands to millions of molecules from natural and synthetic sources. The research projects in this subline are:

Design of new direct-acting antivirals to Zika and Dengue viruses.

Prof. José Villalaín

Identification of natural and synthetic compounds targeting proteins involved in: energy-sensing; inflammatory/oxidative stress, and aging related cellular pathways.

Prof. José A. Encinar

Design of anti-inflammatory, analgesic and anti-pruritus compounds.

Prof. Gregorio Fernández Ballester

Identification of antimicrobial natural and synthetic compounds by virtual screening on selected protein targets related to antibiotic resistance.

Profs. José A. Encinar, Gregorio Fernández Ballester

ENVIRONMENTAL SIGNALING AND DISEASE

Understanding environmental factors and their role in our health and disease.

ENVIRONMENTAL SIGNALING AND DISEASE

Understanding the impact of environmental factors in our health and developing ways to prevent and treat disease.

It is becoming clear the environment affects human physiology, development, and disease risk. Environmental cues, including radiation, contaminants, and endocrine disruptors, may reach cells and orchestrate changes in signaling pathways that may include alterations in genes and their expression. As these environmental cues are on the rise, their impact in molecular and cellular processes needs to be understood for effective preventive measurements and the design of countermeasures that attenuate or correct their pathophysiological impact. Additionally, generated knowledge may be useful to implement new testing methods and assist national and international agencies to update and/or implement policies that minimize the impact of the environment in health. The research projects in this subline are:

Generation of optimised and integrated approaches for testing metabolic disrupting compounds.

Profs. Angel Nadal, Esther Fuentes, Ivan Quesada

An integrative strategy of testing systems for identification of EDs related to metabolic disorders.

Profs. Paloma Alonso-Magdalena, Cristina Ripoll, Laura Marroquí

Actions of simoultaneous exposure to endocrine disruptors and high fat diet on pancreatic β-cell and risk of type 2 diabetes mellitus.

Profs. Angel Nadal, Esther Fuentes, Ivan Quesada

Effect of sex hormones and endocrine disruptors in nociceptive signaling: implications in chronic migraine.

Profs. Antonio Ferrer and Asia Fernández-Carvajal

2. MOLECULAR DIAGNOSIS, PROGNOSIS AND THERAPY

Identifying molecular pathological markers and developing diagnostic and prognostic methods.

This line pursues the identification and validation of molecular markers in human and animal pathologies of high prevalence. It is also involved in the development of diagnostic and prognostic methods and therapeutic or preventive strategies.

Composed of a multidisciplinary research team, it covers from molecular aspects to semi-industrial biological actives. This multidisciplinarity is sustained by the contribution of 8 consolidated groups, which provide a balanced composition that favors high competitiveness in scientific contributions, raising resources, training research staff and generating exploitable and transferable technologies. A high level of national and international collaborations with public and private research organizations contribute to an increase in the impact of the activities and their internationalization.

The milestones achieved in this line of research have a high scientific impact, as shown by scientific publications in internationally recognized journals, as well as the generation of unique technologies protected by worldwide patents and licensed out to interested companies.

Our high potential for clinical translation has materialized in close collaboration with the University Hospitals of Elche and Alicante. Industrial exploitation of our results has also led to continuous and consolidated collaborations with biotech and pharmaceutical companies.

MOLECULAR ONCOLOGY

Targeting multi-drug resistance to improve treatment and prognosis of cancer patients.

DIABETES AND METABOLIC DISORDERS

Understanding the molecular mechanisms of disease to identify new forms of therapy.

CHRONIC INFLAMMATION AND PAIN

Developing new compounds for the treatment of pain.

MOLECULAR ONCOLOGY

Targeting multi-drug resistance to improve treatment and prognosis of cancer patients.

IDiBE researchers have focused on the appearance of chemoresistance to antineoplastic drugs (also known as multidrug resistance, MDR) and the serious problem that this represents for the treatment of oncological patients.

This has been approached from three experimental and complementary directions. The first looks into the characterization of the molecular alterations associated with the acquisition and development of chemoresistance, by studying the interrelations between MDR, apoptosis, and differentiation in tumor cells, or the mechanisms that regulate the expression of proteins associated to the MDR phenotype at transcriptional and post-transcriptional levels. The final goal of these investigations is to be able to overcome or neutralize the MDR developed by some tumors. The second line of interest is pancreatic cancer, one of the cancers with the worst therapeutic prognostic.

Screening and development of new anticancer compounds targeting energy-sensing metabolism and cell proliferation.

Profs. María Herranz, José A. Encinar, Enrique Barrajón and Vicente Micol

Modulation of multidrug resistance.

Profs. Miguel Saceda and Pilar García

Macromolecular interactions and druggability of intrinsically disordered proteins involved in pancreatic cancer.

Profs. José L. Neira, Javier Gómez and Rocio Esquembre

DIABETES AND METABOLIC DISORDERS

Understanding the molecular mechanisms of disease to identify new forms of therapy.

The main objectives of this subline are to understand the molecular mechanisms underlying diabetes and metabolic disorders and to analyze the effect of fatty acids and aging. It also aims at the identification of new proteins and signaling pathways in pancreatic cells that give protection against stressors of diabetes. These studies aim to identify new therapeutic strategies to combat diabetes, including new selective estrogen receptors.

Complementarily, these studies will focus on:

  • A mechanism-of-action profiling-based strategy of pathways related to metabolic stress. This is carried out in cellular models aimed at identifying active compounds and metabolites able to rescue a phenotype consistent in the alleviation of cellular metabolic stress.
  • Testing of bioactive molecules designed to alleviate metabolic stress
  • Searching for dietary polyphenols able to modulate adipose tissue plasticity from white adipose tissue (WAT) to beige adipose tissue (BAT)
  • Assaying the capacity of plant polyphenols to ameliorate metabolic disturbances in hyperlipidemic mice or diet-induced obese mice. Metabolomic analysis to identify changes in metabolites related to energy metabolism.
  • Searching for plant polyphenols that modulate satiety-related hormones and peptides in animal models.
  • Assaying the effects of plant polyphenols on visceral adipose tissue, cardiac adiposity, regional myocardial function, arterial pressure as well as inflammation and oxidative stress in diet-induced obese mice. Polyphenolic extracts from edible plants for the design of advanced nutraceuticals that modulate energy metabolism: applications in the prevention of obesity.

Actions of simultaneous exposure to endocrine disruptors and high fat diet on pancreatic β-cell and risk of type 2 diabetes mellitus

Profs. Angel Nadal, Esther Fuentes

Study of the mechanisms driving type 2 diabetes mellitus disease.

Profs. Angel Nadal, Paloma Alonso-Magdalena

Function of pancreatic α and β-cell during aging: implications for glucose homeostasis.

Profs. Iván Quesada, Cristina Ripoll

Discovery of new targets for the treatment of type 1 and type 2 diabetes based on pancreatic alpha-cell strategies to survive.

Dr. Laura Marroquí

The role of TGFb signaling in maternal metabolic adaptations during pregnancy: implications for the development of gestational diabetes mellitus.

Prof. Paloma Alonso-Magdalena

Mechanism-of-action profiling pathways related to metabolic stress in cell models aimed to identify active compounds and metabolites able to alleviate cellular metabolic stress.

Profs. Vicente Micol, Enrique Barrajón, and María Herranz

Targeting brown adipose tissue plasticity with dietary plant polyphenols: a new strategy to alleviate metabolic disorders.

Profs. María Herranz, Enrique Barrajón and Vicente Micol

Assaying the capacity of plant polyphenols to ameliorate obesity-related metabolic disturbances and modulate satiety-related hormones and peptides.

Profs. María Herranz, Enrique Barrajón and Vicente Micol

Metabolomic and metabonomic analysis to identify biomarkers and metabolites derived from bioactive molecules and related to energy metabolism.

Profs. María Herranz,
Enrique Barrajón and Vicente Micol

CHRONIC INFLAMMATION AND PAIN

Developing new compounds for the treatment of pain.

This subline is centered in discovering and developing new lead compounds for the treatment of chronic inflammatory pain and chronic pruritus, two nociceptive modalities of the dysfunctional peripheral nervous system. Modulators of the thermoTRP channel TRPV1 have been identified and are currently in clinical development for the treatment of chronic postsurgical pain. This success will be extended to other chronic pain syndromes, as well as to chronic pruritus. The main focus will be towards thermoTRP channels, which are central in the generation of peripheral nociceptive signaling, and pain transduction.

Complementarily, type C phospholipases will be used to develop new analgesic and anti-inflammatory candidates for drug development. These enzymes have been traditionally considered undruggable, but we have developed a strategy that has produced hit compounds with a promising potential for clinical development.

Modulators of chronic migraine and arthritic pain.

Profs. Asia Fernández-Carvajal and Antonio Ferrer

Validations of modulators for undruggable phospholipases as new treatments of chronic pruritus.

Profs. Asia Fernández-Carvajal and Antonio Ferrer

ANTIVIRAL AND ANTIMICROBIAL STRATEGIES

Identification of compounds for the prevention and treatment of microbial and viral diseases.

CLINICAL PHARMACOLOGY

Virtual screening of structural databases for rational molecular design.

ANTIVIRAL AND ANTIMICROBIAL STRATEGIES

Identification of compounds for the prevention and treatment of microbial and viral diseases.

Even though great advances have been made in the field of biomedicine in the past 25 years, infectious diseases of a viral and microbial nature are still a serious problem because of its important health, social and economic impact. For example, the threats from recent viral epidemics, along with the emergence of neglected viral infections are a sufficient illustration of this societal challenge.

Viral pandemics are not only centered on human health but also affect animals. For instance, rhabdovirus infections of salmonids is a notable problem in aquiculture that requires a scientific solution. Similarly, the growing antibiotic resistance represents a noteworthy health problem. In this context, it is evident that the prevention of these diseases is of special relevance in both human and animal health.

Identification of antimicrobial plant extracts and compounds against resistant bacteria. Synergic pharmacological behavior between plant polyphenols and antibiotics.

Profs.José A. Encinar, Enrique Barrajón and Vicente Micol

Detection of resistance determinants and genes associated to antibiotics susceptibility in MRSA treated with antimicrobial plant compounds.

Profs. José A. Encinar, Enrique Barrajón and Vicente Micol

Validation of new direct-acting antivirals to Zika and Dengue viruses.

Profs. Ana María Fernández Escamilla and José Villalaín

Identification of targets in fish nucleated red blood cells to enhance antiviral immunity.

Profs. María del Mar Ortega-Villaizan

Production and evaluation of immune-enhancing and protective effects of antigenic nanostructures against viral diseases of fish.

Profs. María del Mar Ortega-Villaizan and Luís Pérez

Characterization and evaluation of plant extracts with high antiviral and antimicrobial activity against pathogens with significant impact in aquaculture.

Profs. María del Mar Ortega-Villaizan and Luís Pérez

CLINICAL PHARMACOLOGY

Working closely with the healthcare sector to develop compounds for cancer and chronic pain treatment.

The area of clinical pharmacology is focused on two main lines:

  • The study of beta blocker drugs in carcinogenesis.
  • The pharmacology of chronic pain.

These lines are intimately associated with the University Hospital of Alicante, where part of the research activities is being performed as it involves working with patients.

Design and development of nanostructures for biotechnology and biomedicine applications.

Design and development of nanocarriers as vehicles of biologically active compounds.

Bench-to-factory developments of functional ingredients and nutraceuticals

The design and production of nutraceuticals and functional ingredients requires from preclinical and bench design to semi-industrial scale production, formulation and quality check using high-resolution analytical techniques, as well as validation through human trials.

Various biotechnological processes such as chemical or enzymatic semi-synthesis, fermentation, or biocatalysis may be involved in such developments regardless of their context: human or animal health, nutrition or food purposes. Characterization and safety of these ingredients are crucial requirements to properly commercialize a product in this sector. The main sublines in this area are:

Production of bioactive ingredients and nutraceuticals to be tested in human intervention trials focused on obesity/overweight, diabetes and hypertension.

Profs. María Herranz, Enrique Barrajón and Vicente Micol

Production of polyphenols-based nutraceuticals focused on sports performance, muscular damage prevention and recovery.

Profs. María Herranz, Enrique Barrajón
and Vicente Micol

Bioassay-guided screening of plant extracts and compounds through efficacy cell assays with applications in nutricosmetics, hygiene or medical devices.

Profs. María Herranz, Enrique Barrajón and Vicente Micol

Design, efficacy and safety testing, and formulation of skin health products

Profs. María Herranz, José A. Encinar, Enrique Barrajón and Vicente Micol

Optimization of industrial processes for functional beverage production,  and waste management for nutraceutical ingredients, all with a bio-economy perspective.

Profs. Domingo Saura López and Nuria Martí Bruñá

Semi-industrial scale production of nutraceuticals from plants, herbs or by-products.

Prof. Domingo Saura López and Nuria Martí Bruñá

Identification & Purification of bioactive molecules from waste management, and small-scale production herein for biological pest control.

Profs. Domingo Saura López & Manuel Valero Roche

Identification, isolation, culture development and pilot plant scale production of microorganism for feedstock.

Prof. Manuel Valero Roche

Development of new nutritional products from fermentation processes.

Profs. Manuel Valero Roche and Nuria Martí Bruñá

Identification, purification and production of bioactive molecules in functional drinks, fermented drinks, beer and wine.

Prof. Nuria Martí Bruñá

Formulation, development and pilot plant scale production of cosmetic and food functional products.

Profs. Domingo Saura López, Manuel Valero Roche and Nuria Martí Bruñá