STAFF

Dr. José Villalaín Boullón

Professor of Biochemistry and Molecular Biology, Universidad Miguel Hernandez

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Unit
Molecular Diagnostic and Therapies

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Subunit
Antiviral Strategies

Group
Viral Membrane Proteins

jvillalain@umh.es

+ 34 966 65 87 62

RESEARCH FIELDS 

  • Study of the structure and interaction of DENV virus-derived peptide libraries comprising the viral structural and non-structural proteins with model biomembranes, aiming to identify their molecular mechanism and biological function. Screening of peptide libraries to identify membranotropic determinants, characterize the interactions in structural terms, study the structure of the membranotropic segments, and make a detailed study of the interaction, modulation and structure of these peptide segments with membranes and living cells.
  • Developing molecular dynamics bioinformatic tools to study the interaction of viral proteins with biomembranes to find new antivirals and therapeutic targets to develop new leading compounds useful for improved combined therapies.

PROFESSIONAL BACKGROUND

  • Previous positions: 
    1. Assistant Professor in Biochemistry and Molecular Biology – University of Murcia – 1983/1987.
    2. Lecturer in Biochemistry and Molecular Biology – University of Murcia – 1987/1997.
    3.- Lecturer in Biochemistry and Molecular Biology – University “Miguel Hernández” – 1997/2003.
    4. Professor of Biochemistry and Molecular Biology – University “Miguel Hernández” – 2003/present.
  • Postdoctoral position: 
  • PhD with Honors, University of the Basque Country, 1983 (Director: Prof. Antonio V. Xavier).
  • Degree in 

REPRESENTATIVE PUBLICATIONS

Nemésio H. and Villalaín J. (2014)

The Journal of Physical Chemistry B., DOI: 10.1021/jp504911r

Membrane interacting regions of Dengue virus NS2A protein.

Nemésio H. and Villalaín J. (2014)

Biochemistry, DOI: 10.1021/bi500724k

Membranotropic regions of the dengue virus prM protein.

Palomares-Jerez M.F., et al. (2013)

Biochimica et Biophysica Acta, DOI: 10.1016/j.bbamem.2013.04.020

Bisphenol A exposure during pregnancy disrupts glucose homeostasis in mothers and adult male offspring.

Palomares-Jerez F., Nemesio H., Villalaín J. (2012)

Biochimica et Biophysica Acta, DOI: 10.1016/j.bbamem.2012.07.022

The membrane spanning domains of protein NS4B from hepatitis C virus.

Palomares-Jerez F., Nemesio H., Villalaín J. (2012)

Biochimica et Biophysica Acta, DOI: 10.1016/j.bbamem.2012.06.012

Interaction with membranes of the full C-terminal domain of protein NS4B from hepatitis C virus.