Dr. José Villalaín Boullón
Professor of Biochemistry and Molecular Biology, Universidad Miguel Hernandez
Molecular Diagnostic and Therapies
Viral Membrane Proteins
+ 34 966 65 87 62
- Study of the structure and interaction of DENV virus-derived peptide libraries comprising the viral structural and non-structural proteins with model biomembranes, aiming to identify their molecular mechanism and biological function. Screening of peptide libraries to identify membranotropic determinants, characterize the interactions in structural terms, study the structure of the membranotropic segments, and make a detailed study of the interaction, modulation and structure of these peptide segments with membranes and living cells.
- Developing molecular dynamics bioinformatic tools to study the interaction of viral proteins with biomembranes to find new antivirals and therapeutic targets to develop new leading compounds useful for improved combined therapies.
- Previous positions:
1. Assistant Professor in Biochemistry and Molecular Biology – University of Murcia – 1983/1987.
2. Lecturer in Biochemistry and Molecular Biology – University of Murcia – 1987/1997.
3.- Lecturer in Biochemistry and Molecular Biology – University “Miguel Hernández” – 1997/2003.
4. Professor of Biochemistry and Molecular Biology – University “Miguel Hernández” – 2003/present.
- Postdoctoral position:
- PhD with Honors, University of the Basque Country, 1983 (Director: Prof. Antonio V. Xavier).
- Degree in
Palomares-Jerez M.F., et al. (2013)
Biochimica et Biophysica Acta, DOI: 10.1016/j.bbamem.2013.04.020
Bisphenol A exposure during pregnancy disrupts glucose homeostasis in mothers and adult male offspring.
Palomares-Jerez F., Nemesio H., Villalaín J. (2012)
Biochimica et Biophysica Acta, DOI: 10.1016/j.bbamem.2012.06.012
Interaction with membranes of the full C-terminal domain of protein NS4B from hepatitis C virus.