STAFF

Dr. Miguel Saceda Sanchez

Associate Professor of Biochemistry and Molecular Biology, Universidad Miguel Hernandez

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Unit
Molecular Diagnostic and Therapies

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Subunit
Molecular and Cellular Oncology

Group
Chemoresistance and Cancer

msaceda@umh.es

+ 34 966 65 84 32

RESEARCH FIELDS 

  • Molecular mechanisms of cancer cells chemoresistance.
  • Development of new cancer treatment for chemoresistance tumours.
  • Histone deacetylase inhibitors as new therapeutics drugs in cancer.
  • Molecular mechanisms of apoptosis as potential new targets in cancer.

PROFESSIONAL BACKGROUND

  • Previous positions: 
    1. Fellowship from FIS (Ministerio de Sanidad). (1982-1985).
    2. Fellowship from Spanish-USA joint Commite (1986-1988).
  • Postdoctoral positions: 
    1. N I H, Bethesda, MD, U.S.A. Estrogen receptor and breast cancer. (1986-88).
    2. Georgetown University, Washington DC, U.S.A. Estrogen receptor and breast cancer. (1988-1993).
    3. Georgetown University, Washington D.C., U.S.A. Estrogen receptor and breast cancer. (1997-98).
    4. Universidad Miguel Hernández. Biochemestry and Molecular Biology Deparment (Research contract Generalitat Valenciana). (1998-2000).
    5. Hospital General Universitario de Elche (Research contract Spanish Healt Ministry). (2000-2006).
    6. Fundación para la Investigación Biomédica del Hospital general Universitario de Elche. (2006-Actual).
  • PhD: Universidad Complutense de Madrid (Director. Dra. Isabel Valverde Alonso), 1986.
  • Degree in Biology.

REPRESENTATIVE PUBLICATIONS

Gomez-Martinez, A., et al. (2007)

Molecular Cancer Research, DOI: 10.1158/1541-7786.MCR-06-0177

Post-transcriptional regulation of P-glycoprotein expresión in colon carcinoma cell lines.

García-Morales P., et al. (2007)

Oncogene, DOI: 10.1038/sj.onc.1210534

Inhibition of Hsp90 function by ansamycin causes downregualtion of cdc2 and cdc25c and G(2)M arrest in glioblastoma cell lines.

García-Morales, P., et al. (2006)

Molecular Cancer Therapies, DOI: 10.1158/1535-7163.MCT-05-0363

Cyclin D3 is downregulated by rapamycin in HER-2-overexpresing breast cancer cells.

García-Morales, P., et al. (2005)

Molecular Cancer Therapeutics, DOI: 10.1158/1535-7163.MCT-04-0186

Histone deacetylase inhibitors induced caspase-independent apoptosis in human pancreatic adenocarcinoma cell lines.

Castro-Galache M.D., et al. (2003)

International Journal of Cancer

Apoptosis induction and down-regulation of P-glycoprotein by Trichostatin A in a Daunorubicin-Resistant murine leukemia cell line.