STAFF

Dr. José Luis Neira Faleiro

Professor of Physical Chemistry, Universidad Miguel Hernandez

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Unit
Molecular and Cellular Design

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Subunit
Molecular Recognizement and Protein Engineering

Group
Structure of Biomolecules

jlneira@umh.es

+ 34 966 65 84 59

RESEARCH FIELDS 

  • Structure of biomolecules.
  • NMR.
  • Fluorescence.
  • Binding.
  • Biophysics.
  • Protein-drug interactions.
  • Peptides.
  • Circular dichroism.

PROFESSIONAL BACKGROUND

  • Previous positions: 
    1. Fellow of Introduction to Research (2 years), CSIC Instituto de Estructura de la Materia, CSIC. 1/01/1988.
    Ph. D. fellow, MEC (4 years). Instituto de Estructura de la Materia, CSIC. 1/01/1990.
    2. Short-term EMBO fellow (6 weeks). Laboratory of Protein Function and Design, MRC, University of Cambridge UK. 1/07/1991.
    3. Long-term EMBO fellow, 3 months. Laboratory of Protein Function and Design, MRC, University of Cambridge UK. 1/03/1994.
    4. Human Capital and Mobility fellow (24 months). Laboratory of Protein Function and Design, MRC, University of Cambridge UK. 1/06/1994.
    5. Contract for a non-clinical research scientist of MRC, UK, 7 months Laboratory of Protein Function and Design, MRC, University of Cambridge UK. 1/06/1996.
    6. Postdoctoral fellow MEC (PFPI), 24 months. Laboratory of Protein Function and Design, MRC, University of Cambridge UK. 1/01/1997.
    7. Consulting works for the company Cambridge Combinatorial Ltd, 4 months Cambridge Combinatorial, The Merrifield centre, Rosemary Lane, Cambridge, UK. 1/11/1998.
    8. Contract for a non-clinical research scientist of MRC, UK, 2 months Laboratory of Protein Function and Design, MRC, University of Cambridge UK. 1/01/1999.
    Contract of MEC, 4 months. Instituto de Estructura de la Materia, CSIC. 1/03/1999.
    9. Assistant professor (interim). University Miguel Hernández, Elche (Alicante) Spain. 1/7/1999-21/3/2002.
  • Postdoctoral positions:
    1. Long-term EMBO fellow, 3 months. Laboratory of Protein Function and Design, MRC, University of Cambridge UK. 1/03/1994.
    Human Capital and Mobility fellow (24 months). Laboratory of Protein Function and Design, MRC, University of Cambridge UK. 1/06/1994.
    2. Contract for a non-clinical research scientist of MRC, UK, 7 months. Laboratory of Protein Function and Design, MRC, University of Cambridge UK. 1/06/1996.
    Postdoctoral fellow MEC (PFPI), 24 months. Laboratory of Protein Function and Design, MRC, University of Cambridge UK. 1/01/1997.
    Consulting works for the company Cambridge Combinatorial Ltd, 4 months Cambridge Combinatorial, The Merrifield centre, Rosemary Lane, Cambridge, UK. 1/11/1998.
    3. Contract for a non-clinical research scientist of MRC, UK, 2 months Laboratory of Protein Function and Design, MRC, University of Cambridge UK. 1/01/1999. 
  • PhD in Chemistry with Honors and Prize to the best Thesis in the whole Universidad Complutense de Madrid (1993).
  • Degree in Chemistry.

REPRESENTATIVE PUBLICATIONS

Bravo J. and Neira J.L. (2010)

The Scientific World Journal, DOI: 10.1100/tsw.2010.158

Folded and unfolded conformations of proteins involved in pancreatic cancer: a layman’s guide.

Aguado-Llera D., et al. (2010)

Biochemistry, DOI:  10.1021/bi901616z

The basic helix-loop-helix region of human neurogenin 1 is a monomeric natively unfolded protein which forms a “fuzzy” complex upon DNA binding.

López-Redonde M.L.., et al. (2010)

FEBS Letters, DOI: 10.1016/j.febslet.2010.01.043

The regulatory factor SipA is a highly stable beta-II class protein with a SH3 fold.

Neira J.L. and Carbajo R.J. P. (2010)

EMBO Reports, DOI: 10.1038/embor.2009.260

The Bronze Age of science in Spain.

Neira J.L. (2009)

The FEBS Journal, DOI: 10.1111/j.1742-4658.2009.07314.x

Interactions between small molecules and the capsid protein of HIV-1: designing inhibitors of capsid assembly.