STAFF

Dr. Ángel Nadal

Professor of Physiology, Universidad Miguel Hernandez

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Unit
Molecular and Cellular Design

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Subunit
Environmental Signaling and Disease

Group
Diabetes Research Unit

nadal@umh.es

+34 96 522 2002

RESEARCH FIELDS 

  • We work to understand the role that estrogen receptors ERα, ERβ and GPER1 have in the physiology of the islet of Langerhans. This will give light on how estrogens influence the plasticity of the endocrine pancreas during the adaptation to pregnancy and obesity. We are interested in the role that endocrine disruptors, particularly those with estrogenic activity, have in the etiology of Diabetes.

PROFESSIONAL BACKGROUND

  • Previous positions:

1. Associate Professor, Department of Physiology, Miguel Hernández University of Elche, Spain, 1998-2009.
2. Lecturer in Physiology, Physiology Group, King’s College London, London, UK, 1995-1996.

  • Postdoctoral positions:

1. Department of Physiology, Miguel Hernández University of Elche, Alicante, Spain, 1997-1998.
2. Physiology Group, King’s College London, London, UK, 1993-1995.

 

  • PhD in Chemistry, Neuroscience Program, Institute of Neurosciences, University of Alicante, Alicante, Spain, 1992.
  • Degree in Chemistry (Biochemistry and Molecular Biology), Autonomous University of Madrid, Madrid, Spain, 1989.

REPRESENTATIVE PUBLICATIONS

Martínez-Pinna J., marroquí L., et al. (2019)

Diabetologia, DOI: 10.1007/s00125-019-4925-y

Oestrogen receptor β mediates the actions of bisphenol-A on ion channel expression in mouse pancreatic beta cells.

Nadal A., et al. (2017)

Nature Reviews Endocrinology, DOI: 10.1038/nrendo.2017.51

Endocrine-disrupting chemicals and the regulation of energy balance.

Villar-Pazos S., Martínez-Pinna J., et al. (2017)

Scientific Reports, DOI: 10.1038/s41598-017-11995-3

Molecular mechanisms involved in the non-monotonic effect of bisphenol-a on Ca2+ entry in mouse pancreatic β-cells.

García-Arévalo M., et al. (2016)

Endocrinology, DOI: 10.1210/en.2016-1390

Maternal Exposure to Bisphenol-A During Pregnancy Increases Pancreatic β-Cell Growth During Early Life in Male Mice Offspring.

Alonso-Magdalena P., et al. (2013)

Diabetes, DOI: 10.2337/db12-1562

Antidiabetic actions of an ERβ selective agonist.

Soriano S., et al. (2012)

PLoS One, DOI: 10.1371/journal.pone.0031109

Rapid insulinotropic action of low doses of bisphenol-A on mouse and human islets of Langerhans: role of estrogen receptor beta

PATENTS AND AVAILABLE TECHNOLOGIES

Utilización del 17beta-estradiol, sus análogos y derivados en el tratamiento de la diabetes mellitus y sus manifestaciones

Inventors: B. Soria, A. Nadal, C. Ripoll, J.M. Rovira, E. Andreu, O. Laribi y T. León-Quinto.
Number: P9800625.
 
Date: 24 de marzo 1998
Countries: Spain