STAFF

Dr. Vicente Micol Molina

Professor of Biochemistry, Universidad Miguel Hernandez

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Unit
Molecular Diagnosis and Therapy

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Subunit
Bioactive Molecules

Group
Natural Bioactive Compounds and Biomembranes

vmicol@umh.es

+ 34 966 65 84 30

RESEARCH FIELDS 

The relationship between the biological activity of natural dietary compounds and its effects on chronic human diseases is under intense debate. The research target of our group is to characterize the wide biological activity of natural bioactive compounds using cellular and animal models and to understand the mechanism underlying their health effects. Our group is focused on:

  • The capacity of polyphenols to ameliorate metabolic disturbances (oxidative stress and insulin resistance) in cellular models and hyperlipidemic mice.
  • Bioguided screening of antimicrobial herbal extracts and compounds for applications in cosmetics, hygiene or medical devices. 
  • The cytotoxic/cytostatic and apoptotic effects of polyphenols in cancer cellular models using global OMICs. Nano-encapsulation of potential anticarcinogenic compounds.
  • Characterization of food and herbal materials by chromatography coupled to mass spectrometry. Semi-industrial scale production of herbal extracts deriving from plants or vegetal by-products. Optimization of juice extraction processes and integral exploitation of by-products.

PROFESSIONAL BACKGROUND

  • Previous positions: Department of Biochemistry and Molecular Biology. Veterinary Faculty. University of Murcia (Spain). Teaching Assistant. Regulation of protein kinase C activity by lipids and phytochemicals (1994-1997).
  • Postdoctoral positions: Division of Biology, California Institute of Technology (Caltech), Pasadena (California). Senior Research Fellow (Fulbright Commission). The molecular mechanism of human mitochondrial miopathies. Molecular characterization and cloning of the transcription termination factor of the human mitochondrial DNA. Prof. Giuseppe Attardi Laboratory (1991-1994).
  • PhD programme: PhD degree with Honors, University of Murcia (Director: Prof. Juan Carmelo Gómez-Fernández), 1990.
  • Degree in Chemistry and Biochemistry.

REPRESENTATIVE PUBLICATIONS

Barrajón-Catalán E., et al. (2010)

Cancer Letters, DOI: 10.1016/j.canlet.2009.09.010

Selective death of human breast cancer cells by lytic immunoliposomes: Correlation with their HER2 expression level.

Funes, L., et al. (2009)

Food Chemistry, DOI: 10.1016/j.foodchem.2009.04.059

Correlation between plasma antioxidant capacity and verbascoside levels in rats after oral administration of lemon verbena extract.

Micol V., et al. (2005)

Antiviral Research, DOI: 10.1016/j.antiviral.2005.02.005

The olive leaf extract exhibits antiviral activity against viral haemorrhagic septicaemia rhabdovirus (VHSV).

Alves D.S., et al. (2004)

Biochemical Pharmacology, DOI: 10.1016/j.bcp.2004.04.012

Membrane-related effects underlying the biological activity of the anthraquinones emodin and barbaloin

Caturla N., et al (2003)

Journal of Medicinal Chemistry, DOI: 10.1016/S0891-5849(02)01366-7

The relationship between the antioxidant and the antibacterial properties of galloylated catechins and the structure of phospholipid model membranes

PATENTS AND AVAILABLE TECHNOLOGIES

Método de producción de pectina modificada de cítricos

Inventores: D. Saura, N. Martí, V. Micol, L. Funes, S. Vegara, G. Ignatieva, E. Barrajón Catalán, M. Valero, P. Mena, R. Martínez, Mª. R. Berenguer, M. Moliner.
Titular: Universidad Miguel Hernández.
Nº : P201301183 (11/12/2013). España.

Método de fabricación de pectina acromática normalizada

Inventores: G. Ignatieva, D. Saura, N. Martí, V. Micol, S. Vegara, E. Barrajón Catalán, M. Valero, P. Mena, R. Martínez, Mª R. Berenguer, M. Moliner.
Titular: Mitra Sol Technologies, S.L.- UMH.
Nº : P201301184 (11/12/2013). España.

Combinación sinérgica de flavonoides y Vit C

Inventores: N. Martí, D. Saura, P. Mena, V. Micol, M. Valero, R. Martínez, S. Vegara, L. Funes, E. Barrajón-Catalán, C. García.
Titular: Universidad Miguel Hernández.
Nº : ES201300578 (05/06/2013). España.

Equipo de expansión instantánea a vacío y ultrasonidos

Inventores: N. Martí, D. Saura, V. Micol, S. Vegara, E. Barrajón-Catalán, M. Valero, R. Martínez, Mª R. Berenguer, E. Bernat.
Titular: Mitra Sol Technologies, S.L.-UMH.
Nº : PCT/ES2013/000191 (08/08/2013).

COMPANY AGREEMENTS

  • Contracts and agreements of collaboration with companies for the evaluation of the efficacy, quality, safety and development of cosmetics and nutricosmetics (INVITROTECNIA, MONTELOEDER, QUIMICAS DEL VINALOPÓ, ENDEMIC BIOTECH).
  • Contracts and agreements of collaboration with companies for the evaluation of the quality, stability and safety of biocides and phytosanitary products (IBERFOL).
  • Contracts and agreements of collaboration with companies for the evaluation of the efficacy, quality, safety and development of ingredients for functional food and nutraceuticals (MONTELOEDER, NUTRAFUR, NINAPHARM, LABORATORIUM MEDISAN, PRAXIS, BIOSASUN).