STAFF

Dr. Isabel Martínez-Lacaci Fortuny

Associate Professor of Biochemistry and Molecular Biology, Universidad Miguel Hernandez

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Unit
Molecular Diagnostic and Therapies

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Subunit
Molecular and Cellular Oncology

Group
Chemoresistance to antineoplasic drugs

imlacaci@umh.es

+ 34 966 65 84 77

RESEARCH FIELDS 

  • Studies of molecular mechanisms of action of potential antineoplasic drugs through the study of signal transduction mechanisms linked to cell cycle regulation.
  • Identificaction of novel molecular targets through pharmacogenomic and pharmacoproteomic studies.
  • Validation of tyrosine kinase inhibitors as novel antitumor agents in cancer.
  • Chemoresistance and antineoplasic drugs.

PROFESSIONAL BACKGROUND

  • Previous positions:
    1. Research Associate at the Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. 1999-2003.
    2. “Ramón y Cajal” Investigator at the Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, Elche (Alicante), Spain. 2003-2008.
  • Postdoctoral positions: Postdoctoral fellow at the Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Studies of regulation of growth factors and receptors in mammmary epithelial and breast cancer cells.(Prof. David S. Salomon) 1995-1999
  • PhD programme: PhD with Honors, Georgetown University, Washington, DC, USA (Director: Prof. Robert B. Dickson), 1995.
  • Degree in Biology. 

REPRESENTATIVE PUBLICATIONS

Menéndez-Gutiérrez J.A., et al. (2010)

Molecular Cancer Therapeutics, DOI: 10.1158/1535-7163.MCT-10-0233

Serine Proteases in Histone Deacetylase Inhibitor-Induced Apoptosis Still an Unresolved Question.

García-Morales P., et al. (2007)

Oncogene, DOI: 10.1038/sj.onc.1210534

Inhibition of Hsp90 function by ansamycins causes dowregulation of cdc2 and cdc25c and G2/M arrest in glioblastoma cell lines.

García-Morales P., et al. (2006)

Molecular Cancer Therapeutics, DOI: 10.1158/1535-7163.MCT-05-0363

Cyclin D3 is downregulated by rapamycin in HER2 overexpressing breast cancer cells.

Martínez-Lacaci I., et al. (2006)

Molecular Cancer Therapeutics, DOI: 10.1002/1097-0215(20001001)88:1<44::AID-IJC7>3.0.CO;2-8

Immobilization and characterization of 2,3-diaminonaphthalene/cyclodextrin complexes in a sol-gel matrix: a new fluorimetric sensor for nitrite.

Martínez-Lacaci I., et al. (1995)

Endocrinology, DOI: 10.1210/endo.136.9.7649107

Estrogen and phorbol esters regulate amphiregulin expression by two separate mechanisms in human breast cancer cell lines.