STAFF

Dr. José Manuel González Ros

Professor of Biochemistry and Molecular Biology, Universidad Miguel Hernandez

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Unit
Molecular and Cellular Design

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Subunit
Structure-function relationships in membrane proteins

Group
Structure-function of potassium ion channels

gonzalez.ros@umh.es

+ 34 966 65 87 57

RESEARCH FIELDS 

  • Structure/Function relationships in membrane proteins: Neuroreceptors and ion channels.
  • Lipid-Protein and Protein-Protein interactions in biological membranes.
  • Potential applications to drug discovery.

PROFESSIONAL BACKGROUND

  • Previous positions:
    1997, Catedrático. Univ. Miguel Hernández
    1987-97, Catedrático. Univ. Alicante
    1984-87, Catedrático. Univ. Islas Baleares
    1981-84, Assistant Professor. Medical College of Virginia, USA
    1980-81, Research Associate. Medical College of Virginia, USA
    1978-80, Research Fellow, Medical College of Virginia, USA
    1977-78, Prof. Adjunto Interino. Univ. Alcalá de Henares
    1976-77, Prof. Encargado. Univ. Complutense de Madrid
    1974-76, Prof. Ayudante. Univ. Complutense de Madrid
    Director, Institute of Molecular and Cellular Biology, 1998-2012.
  • Postdoctoral positions:
  • PhD in Biochemistry, 1977. Universidad Complutense de Madrid (Advisor: Prof. Antonio Ribera Blancafort)
  • Degree in Biological Sciences, 1974.

REPRESENTATIVE PUBLICATIONS

Triano I., et al. (2010)

Biochemistry, DOI: 10.1021/bi1003712

Occupancy of nonannular lipid binding sites on KcsA greatly increases the stability of the tetrameric protein.

Barrera F., et al. (2008)

Biochemistry, DOI: 10.1021/bi700778c

Protein self-assembly and lipid binding in the folding of the potassium channel KcsA.

Renart M.L., et al. (2006)

The Journal of Biological Chemistry, DOI: 10.1074/jbc.M602636200

Effects of conducting and blocking ions on the structure and stability of the potassium channel KcsA.

Molina M.L., et al. (2006)

The Journal of Biological Chemistry, DOI: 10.1074/jbc.M600342200

Clustering and coupled gating modulate the activity in KcsA, a potassium channel model.

Fernández A.M., et al. (2006)

Protein-Lipid interactions: New approaches and emerging concepts (C. R. Mateo, J. Gómez, J.Villalaín and J. M. González Ros, Eds.), pp. 203-231, Springer Series in Biophysics 9. Springer, Heidelberg (2006), DOI: 10.1007/3-540-28435-4_8

Structural and functional modulation of ion channels by specific lipids: from model systems to cell membranes.

PATENTS AND AVAILABLE TECHNOLOGIES

A DEVICE FOR ADMINISTRATION OF MEDICATION BY IONTOPHORESIS FOR LOCAL-REGIONAL TREATMENT

Number: 90100236.0
Date: 1995