STAFF

Dr. Asia Fernández Carvajal

Professor of Biochemistry and Molecular Biology, Universidad Miguel Hernandez

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Unit
Molecular Diagnosis and Therapy

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Subunit
Bioactive Molecules

Group
Pain Signaling: Design of Drugs on TRP Receptors

asia.fernandez@umh.es

+ 34 966 65 84 54

RESEARCH FIELDS 

  • High throughput screening.
  • Discovery and development of anti-nociceptive drugs.
  • Structure-function studies on ion channels.

PROFESSIONAL BACKGROUND

  • Previous positions:
    1. 1988-1991: Predoctoral Fellowship from M.E.C.: Department of Neurochemistry. Medicine Faculty University of Alicante.
    2. 1992-1995: Postdoctoral Fellowship from European Comunity. Investigation in Neuroreceptors and ionic channels.
    3. 1988-1997: Lecturer in Biochemistry. Department of Neurochemistry. Medicine Faculty. University of Alicante.
    4. 1997-2009: Assistant Profesor of Enzimology and Biochemistry. Department of Biochemistry and molecular. UMH University.
  • Postdoctoral positions:  
  • PhD in
  • Degree in Biology.

REPRESENTATIVE PUBLICATIONS

Serafini M., et al. (2018)

Journal of Medicinal Chemistry, DOI: 10.1021/acs.jmedchem.8b00109

Targeting TRPV1 softly: the discovery of Passerini adducts as a topical treatment for inflammatory skin disorders. Journal of Medicinal Chemistry.

Balsera, B., et al. (2018)

European Journal of Medicinal Chemistry, DOI: 10.1016/j.ejmech.2017.10.083

Amino acid and peptide prodrugs of diphenylpropanones positive allosteric modulators of α7 nicotinic receptors with analgesic activity.

Torre-Martínez, R., et al. (2017)

Scientific Reports, DOI: 10.1038/s41598-017-10913-x

Synthesis, high-throughput screening and pharmacological characterization of β-lactam derivatives as TRPM8 antagonists.

Montoya E., et al. (2017)

Biochimica et Biophysica Acta, DOI: 10.1016/j.bbamem.2017.01.014

Differential binding of monovalent cations to KcsA: Deciphering the mechanisms of potassium channel selectivity.

Bertaminoa A., et al.(2016)

Journal of Medicinal Chemistry, DOI: 10.1021/acs.jmedchem.5b01914

Tryptamine-based derivatives as Transient Receptor Potential Melastatin type-8 (TRPM8) channel modulators.

PATENTS AND AVAILABLE TECHNOLOGIES

Compounds which can block the responses to chemical substances or thermal stimuli or mediators of inflammation of nociceptors, production method thereof and compositions containing same

Inventores: Fernández-Carvajal A, García-Martínez C, Belmonte C, Van Den Nest W, Carreño C., Ferrer-Montiel A.
Titular: Universidad Miguel Hernández.
Nº : ES2195787 B1 (granted on 01/06/2005); WO03/097670; EP1506970 A1; US7183430 B2 (granted on 27/02/2003); AU2003/231331; CA2486342 A1; JP2006/502975 ; MX PA/a/04011502.

New bis-N-(halophenethyl)-glycyl-glycine derivatives, useful as analgesic medicaments, especially for treating inflammatory or neuropathic pain, or in cosmetic compositions

Inventores: Antonio Ferrer Montiel, Asia Fernández Carvajal, Carolina García Martínez, Carlos Belmonte Martínez, Wim van den Nest, Cristina Carreño Serraima.
Titular: University of Groningen; EMBL; National University of Ireland.
Nº: WO2003097670-A; WO2003097670-A1; ES2195787-A1; AU2003231331-A1; EP1506970-A1; KR2005007406-A; ES2195787-B1; US2005130907-A1; JP2006502975-W; US7183430-B2.

Pharmaceutical composition for the treatment of the dry eye

Inventores: Carlos Belmonte Martínez, Juana Gallar Martinez, Antonio Ferrer Montiel, Asia Fernández Carvajal, Felix Viana de la Iglesia.
Nº: WO2012/032209 A2 EP2614860A2, EP2614860A4, US20130245231, WO2012032209A3.
 

COMPANY AGREEMENTS

  • BCN Peptides
  • DiverDrugs