STAFF

Dr. José Antonio Encinar Hidalgo

Associate Professor of Biochemistry and Molecular Biology, Universidad Miguel Hernandez

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Unit
Molecular and Cellular Design

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Subunit
Molecular Modeling Platform

Group
Structural Biocomputing

jant.encinar@umh.es

+ 34 966 65 84 53

RESEARCH FIELDS 

  • Structural proteomics and bioinformatics: ADAN database and “In silico” design of peptidic protein-kinase inhibitors.
  • Molecular docking approaches for drug discovery: search inhibitors of Dengue and Zika RNA-dependent RNA polimerases (DOCKING database).

PROFESSIONAL BACKGROUND

  • Previous positions:
    1. Fellowship from Ministerio de Educación y Cultura of Spain, University of Alicante. Department of Neurochemistry. 1994-1997.
    2. Assistant Professor of Biochemistry and Molecular Biology at UMH (1997-2008)
  • Postdoctoral positions:
    1. Department of Cell Biology and Histology, Academisch Medisch Centrum. University of Amsterdam. Floppase activity studies of P-gp protein (MDR1). Cell cultured studies (Prof. Gerrit van Meer).
    2. Institut de Biologie Phisico-Chimique. Universitè Paris VII. France. Floppase activity studies of P-gp protein (MDR1). Biophysical studies (Prof. Philippe Devaux).
    3. European Molecular Biology Laboratory (EMBL). Heidelberg, Germany (2004-2006). Development and implementation of the web site for ADAN database for protein modular domains implied in protein-protein interactions. Computational design of competitive inhibitors and modulators in the superfamily of protein MAPK, CDK, PKA and Aurora kinases (Prof. Luis Serrano).
  • PhD with Honors and Prize to the best Thesis at the Neuroscience program, Universidad Miguel Hernández de Elche. Director: Prof. José Manuel González Ros (1998).
  • Degree in Biology. University of Salamanca (June 1992).

REPRESENTATIVE PUBLICATIONS

Encinar, J.A., et al. (2015)

Drug Design, Development and Therapy, DOI: 10.2147/DDDT.S93449

In silico approach for the discovery of new PPAR-gamma modulators among plant-derived polyphenols.

Molina, M.L., et al. (2015)

The Journal of Biological Chemistry, DOI: 10.1074/jbc.M115.669598

Competing Lipid-Protein and Protein-Protein Interactions Determine Clustering and Gating Patterns in KcsA.

Corral-Rodríguez, M.A., et al. (2014)

Biochemical Journal, DOI: 10.1042/BJ20140409

Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure.

López-Jiménez, A.J., et al. (2014)

Antiviral Research, DOI: 10.1016/j.antiviral.2014.04.009

Hepatitis C virus polymerase-polymerase contact interface: Significance for virus replication and antiviral design..

Poveda JA., et al. (2014)

Biochimica et Biophysica Acta, DOI: 10.1016/j.bbamem.2013.10.023

Lipid modulation of ion channels through specific binding sites.

Martinez-López, A., et al. (2013)

Marine Drugs, DOI: 10.3390/md11072328

pH-dependent solution structure and activity of the host-defense peptide myticin C (Myt C) from the mussel Mytilus galloprovincialis.